Lili Pauline Reinhart was born on September 13, 1996 in Cleveland, en Ohio, USA.She grew up in a neighbour city named Bay Village.
Lili developed a passion for art and shows at an early age which lead her to travel a lot between Ohio and New York to audition for roles she found online with her mom. At the same time, she was taking dance classes and playing in local musicals. When she was 11 Lili appeared on an episode of Law & Order: SVU, her first apparition on TV. In 2011, she meets her manager, Dara Gordon, and sign in an agency.

Lili Reinhart start her carriere in 2010 in the short movie For Today. Then she apeares in a few independent movies such as The Kings of Summer and Forever’s End.
In 2014, she obtain her first lead role in television as Heather Blumeyer on Fox‘s tv series Surviving Jack.
In march 2016, she has her first lead role in a movie as Margot Jensen in Miss Stevens by Julia Hart in which she share the screen with Lily Rabe and Timothée Chalamet.
In february 2016, she gets the role of Betty Cooper on Riverdale‘s pilot — a tv show based on the characters from Archie Comics. The show airs on January 26, 2017 on The CW and on Netflix.
In 2018, she is cast on an english movie name Galveston directed by the french actress Mélanie Laurent where she shares the screen with the famous Elle Fanning. The following year she get on of the lead role in the movie Hustlers joined by Jennifer Lopez, Constance Wu and a solid team of powerful women.
She got her first executive producer job in 2020 on the movie Chemical Hearts and stars in it as Grace Town alongside Austin Abrams. The same year she released her first poetry book named Swimming Lessons in which she shares her own poems based on her experiences and inspirations.